archives

Mouse

This section contains 5 tutorials

Oral Gavage in the Mouse

Oral Gavage in the MouseMaterial can be administered orally using a number of different techniques, although gavage using a stomach tube is the most widely used. To minimise the risk of adverse effects associated with this procedure, it is important that the operator is skilled both in the technique and the restraint method needed…

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Subcutaneous Injection in the Mouse

Subcutaneous Injection in the Mouse

Subcutaneous administration of material often causes minimal pain or discomfort, provided the material is non-irritant, has a near-neutral pH, and is not excessively hypertonic or hypotonic…

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Intravenous Injection in the Mouse

Intravenous Injection in the Mouse

Intravenous administration of material can be technically difficult, and use of a restraining device is often required. These should be selected carefully to be an appropriate size for the animal to be injected. Too small a device can result in injuries to the animal, and can interfere with respiratory movements…

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Intraperitoneal Injection in the Mouse

Intraperitoneal Injection in the Mouse

Although widely used as a means of administering substances, particularly injectable anaesthetics, this is an inherently unreliable technique, since inadvertent injection of some material into the gut, abdominal fat and subcutaneous tissues is a relatively frequent occurrence…

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Handling and Restraint of the Animal

Handling and Restraint of the Animal

Almost all laboratory animals can be restrained safely and humanely provided they are handled correctly. All animals benefit from being first accustomed to being handled, and this can be done during the period of acclimatisation needed before they are used on a research procedure.

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ADMINISTRATION
OF SUBSTANCES

A series of tutorials to assist research workers develop their skills in the administration of substances to laboratory animals.

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